Reduced expression of PBP-2A by neonatal mecA-positive coagulase- negative staphylococci (CoNS) blood isolates: b-lactams are useful first-line agents for the treatment of neonatal CoNS sepsis, restricting the use of vancomycin
نویسندگان
چکیده
Objectives: Vancomycin use for neonatal coagulase-negative staphylococci (CoNS) sepsis is based on a high CoNS carriage rate of mecA, encoding penicillin-binding protein (PBP)-2a, with low affinity for, and associated with resistance to, b-lactam antibiotics. The relationship between mecA gene carriage, phenotypic expression of the gene by PBP-2a production and in vitro resistance to the b-lactam antibiotics oxacillin, cefazolin and amoxicillin/clavulanate was determined for 85 CoNS blood isolates randomly obtained from our collection of isolates from neonates with CoNS sepsis.
منابع مشابه
Determination of the Frequency of Microbial Agents and Drug Susceptibility Pattern of the Neonatal Sepsis in the Neonatal Intensive Care Unit at Alzahra Hospital, Tabriz, Iran
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